Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion
نویسندگان
چکیده
منابع مشابه
Characterization of White Matter Injury in a Rat Model of Chronic Cerebral Hypoperfusion.
BACKGROUND AND PURPOSE Chronic cerebral hypoperfusion can lead to ischemic white matter injury resulting in vascular dementia. To characterize white matter injury in vascular dementia, we investigated disintegration of diverse white matter components using a rat model of chronic cerebral hypoperfusion. METHODS Chronic cerebral hypoperfusion was modeled in Wistar rats by permanent occlusion of...
متن کاملWhite matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion.
BACKGROUND AND PURPOSE Cerebrovascular white matter (WM) lesions are closely associated with cognitive impairment and gait disorders in the elderly. We have successfully established a mouse model of chronic cerebral hypoperfusion that may provide new strategies for the molecular analysis of cerebrovascular WM lesions. METHODS Adult C57Bl/6 male mice were subjected to bilateral common carotid ...
متن کاملCilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion.
BACKGROUND AND PURPOSE White matter lesions contribute to cognitive impairment in poststroke patients. The present study was designed to assess the neuroprotective mechanisms of cilostazol, a potent inhibitor of type III phosphodiesterase, through signaling pathways that lead to activation of transcription factor cAMP-responsive element binding protein (CREB) phosphorylation using rat chronic c...
متن کاملDiazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.
Aging and dementia are accompanied by cerebral white matter (WM) injury, which is considered to be of ischemic origin. A causal link between cerebral ischemia and WM damage has been demonstrated in rats; however, few attempts appear to have been made to test potential drugs for the alleviation of ischemia-related WM injury. We induced cerebral hypoperfusion via permanent, bilateral occlusion of...
متن کاملCorrection: White Matter Injury Due to Experimental Chronic Cerebral Hypoperfusion Is Associated with C5 Deposition
The C5 complement protein is a potent inflammatory mediator that has been implicated in the pathogenesis of both stroke and neurodegenerative disease. Microvascular failure is proposed as a potential mechanism of injury. Along these lines, this investigation examines the role of C5 in the setting of chronic cerebral hypoperfusion. Following experimental bilateral carotid artery stenosis, C5 pro...
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ژورنال
عنوان ژورنال: Stroke
سال: 2016
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.115.011679